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The Mohi LabMohiLAB

Principal Investigator

Golam Mohi, PhD

Principal Investigator

Research interest

Cell signaling, hematopoietic stem cell biology, and the molecular pathogenesis of myeloproliferative neoplasms and myelodysplastic syndromes. Bench-to-clinic work on PIM1 inhibition (TP-3654 / Nuvisertib, NCT04176198).

Links

Selected publications.

37 papers on which Mohi’s name appears. Sorted by year.

  1. 01

    2026Blood

    The C/EBPα-(PU.1-LOUP) regulatory circuit regulates monocyte/macrophage development and immune functions

    Waliullah ASM, Nguyen TA, Dziegielewska B, Zhang J, Qiu K, Tran ML, Nguyen NN, Wang L, Pan A, Nong MK, Segovia N, Li Y, Zhang Y, Ummarino S, Nguyen TM, Manichaikul A, Ghosh P, Mohi G, Goldfarb AN, Craig JW, Tenen DG, Trinh BQ

    PMID 41592329 ↗

  2. 02

    2025Haematologica

    A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera

    Shan Y, DeSouza N, Littman N, Qiu Q, Nguyen K, Yu Y, Mohi G, Li S

    PMID 40468940 ↗

  3. 03

    2023Blood Cancer Journal

    SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm

    Yang Y, Abbas S, Sayem MA, Dutta A, Mohi G

    PMID 38012156 ↗

  4. 04

    2022Nature Communications

    Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm

    Rahman MF, Yang Y, Le BT, Dutta A, Posyniak J, Faughnan P, Sayem MA, Aguilera NS, Mohi G

    PMID 36100596 ↗

  5. 05

    2022Leukemia

    Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models

    Dutta A, Nath D, Yang Y, Le BT, Rahman MF, Faughnan P, Wang Z, Stuver M, He R, Tan W, Hutchison RE, Foulks JM, Warner SL, Zang C, Mohi G

    PMID 34741118 ↗

  6. 06

    2021Cancer Research

    CDK6 Is a Therapeutic Target in Myelofibrosis

    Dutta A, Nath D, Yang Y, Le BT, Mohi G

    PMID 34145036 ↗

  7. 07

    2021Leukemia

    U2af1 is required for survival and function of hematopoietic stem/progenitor cells

    Dutta A, Yang Y, Le BT, Zhang Y, Abdel-Wahab O, Zang C, Mohi G

    PMID 33414485 ↗

  8. 08

    2019JACC: Basic to Translational Science

    JAK2 (V617F)-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

    Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K

    PMID 31709318 ↗

  9. 09

    2018British Journal of Haematology

    STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice

    Dutta A, Yan D, Hutchison RE, Mohi G

    PMID 28025836 ↗

  10. 10

    2017Blood

    Hmga2 promotes the development of myelofibrosis in Jak2(V617F) knockin mice by enhancing TGF-β1 and Cxcl12 pathways

    Dutta A, Hutchison RE, Mohi G

    PMID 28637665 ↗

  11. 11

    2017Leukemia

    Deletion of Ptpn1 induces myeloproliferative neoplasm

    Jobe F, Patel B, Kuzmanovic T, Makishima H, Yang Y, Przychodzen B, Hutchison RE, Bence KK, Maciejewski JP, Mohi G

    PMID 28111468 ↗

  12. 12

    2016Blood

    Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm

    Yang Y, Akada H, Nath D, Hutchison RE, Mohi G

    PMID 27081096 ↗

  13. 13

    2016Blood

    Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

    Gu S, Chan WW, Mohi G, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA

    PMID 26773044 ↗

  14. 14

    2015Leukemia

    Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice

    Yan D, Jobe F, Hutchison RE, Mohi G

    PMID 26044284 ↗

  15. 15

    2014Stem Cells

    Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells

    Akada H, Akada S, Hutchison RE, Wagner KU, Mohi G

    PMID 24677703 ↗

  16. 16

    2014Leukemia

    Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice

    Akada H, Akada S, Hutchison RE, Mohi G

    PMID 24480985 ↗

  17. 17

    2012Blood

    Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in mice

    Yan D, Hutchison RE, Mohi G

    PMID 22837531 ↗

  18. 18

    2012Blood

    Efficacy of vorinostat in a murine model of polycythemia vera

    Akada H, Akada S, Gajra A, Bair A, Graziano S, Hutchison RE, Mohi G

    PMID 22408262 ↗

  19. 19

    2012Haematologica

    Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice

    Akada H, Akada S, Hutchison RE, Mohi G

    PMID 22371173 ↗

  20. 20

    2012Blood

    Critical requirement for Stat5 in a mouse model of polycythemia vera

    Yan D, Hutchison RE, Mohi G

    PMID 22144185 ↗

  21. 21

    2011FEBS Letters

    Differential biological activity of disease-associated JAK2 mutants

    Zou H, Yan D, Mohi G

    PMID 21362419 ↗

  22. 22

    2010Blood

    Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

    Akada H, Yan D, Zou H, Fiering S, Hutchison RE, Mohi MG

    PMID 20197548 ↗

  23. 23

    2009Blood

    Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

    Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG

    PMID 19179468 ↗

  24. 24

    2007Cancer Biology & Therapy

    Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer

    Masiello D, Mohi MG, McKnight NC, Smith B, Neel BG, Balk SP, Bubley GJ

    PMID 17218776 ↗

  25. 25

    2007Current Opinion in Genetics & Development

    The role of Shp2 (PTPN11) in cancer

    Mohi MG, Neel BG

    PMID 17227708 ↗

  26. 26

    2005Molecular and Cellular Biology

    Phosphatidylinositol 3-kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences

    Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T

    PMID 16135792 ↗

  27. 27

    2005Cancer Cell

    Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

    Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG

    PMID 15710330 ↗

  28. 28

    2004Nature Medicine

    Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

    Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG

    PMID 15273746 ↗

  29. 29

    2004Proceedings of the National Academy of Sciences USA

    Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

    Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG

    PMID 14976243 ↗

  30. 30

    2002Cancer Cell

    Critical role for Gab2 in transformation by BCR/ABL

    Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, Gu H, Griffin JD, Neel BG

    PMID 12124177 ↗

  31. 31

    2000Infection and Immunity

    Enterotoxin-specific immunoglobulin E responses in humans after infection or vaccination with diarrhea-causing enteropathogens

    Qadri F, Asaduzzaman M, Wennerås C, Mohi G, Albert MJ, Abdus Salam M, Sack RB, Jertborn M, McGhee JR, Sack DA, Holmgren J

    PMID 10992527 ↗

  32. 32

    2000Oncogene

    Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF

    Liu R, Liu CB, Mohi MG, Arai K, Watanabe S

    PMID 10698527 ↗

  33. 33

    1998Molecular Biology of the Cell

    Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system

    Mohi MG, Arai Ki, Watanabe S

    PMID 9843570 ↗

  34. 34

    1997Infection and Immunity

    Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1

    Qadri F, Wennerås C, Albert MJ, Hossain J, Mannoor K, Begum YA, Mohi G, Salam MA, Sack RB, Svennerholm AM

    PMID 9284121 ↗

  35. 35

    1996Clinical and Diagnostic Laboratory Immunology

    Monoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic application

    Qadri F, Mohi MG, Chowdhury A, Alam K, Azim T, Sears C, Sack RB, Albert MJ

    PMID 8877146 ↗

  36. 36

    1996Journal of Diarrhoeal Diseases Research

    Production, characterization and immunodiagnostic application of a monoclonal antibody to Shiga toxin

    Qadri F, Mohi MG, Azim T, Faruque SM, Kabir AK, Albert MJ

    PMID 8870402 ↗

  37. 37

    1995Clinical and Diagnostic Laboratory Immunology

    Comparison of the vibriocidal antibody response in cholera due to Vibrio cholerae O139 Bengal with the response in cholera due to Vibrio cholerae O1

    Qadri F, Mohi G, Hossain J, Azim T, Khan AM, Salam MA, Sack RB, Albert MJ, Svennerholm AM

    PMID 8574829 ↗

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